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Memories Of White Pond
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How a Pond Snail Could Someday Improve Your Memory
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Eric Kandel , a neuroscientist at Columbia University, has researched memory in sea slugs and mice for years, so much so that in he won a Nobel Prize for his work. The neurons in these snails are very large, and they're great for electrophysiological recording. Electrophysiology, another name for electrophysiological recording, is the study of electrical properties of biological cells and tissues. It can help doctors understand abnormal heart rhythms, and it can also help scientists investigate memory and how it's formed.
Now, new research coming out of the University of Sussex could provide insight into human memory by studying great pond snails. The study, published in Scientific Reports, could give some clues for understanding how trauma is remembered, and how memories can be controlled and manipulated. They notoriously haunt trauma patients, such as war veterans suffering from post-traumatic stress disorder, with dark memories from their past.
Neural networks can't be easily studied in humans, in large part because scientists can't dissect living people's brains. Such studies would be unethical, not to mention illegal. But with snails, it's different.
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For this study, Korneev and other researchers trained snails to perform certain activities, and then extracted their brains during different stages of memory formation. From there, they found, sequenced, and compared molecules. They specifically homed in on microRNAs, very short RNA constructions that do not code proteins but are crucial for forming long-term memories. They took turns regulating the memory-forming proteins and identified a molecule called microRNA The next step, Korneev says, is to try to track down other molecules that are involved directly in long-term memory formation.
There are hundreds of different types of microRNAs in the human brain, and this published paper only investigates one of them. This study marks the first time that specific microRNAs have been shown to be important for forming long-term memories after a single episode of learning.
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