This might be due to lacking compliance of these patients. They might worry about further side effects from ET and the long duration of therapy. The most frequently applied form of systemic treatment was a combination of CHT and ET in premenopausal and ET alone in postmenopausal patients. The Oxford Overview Pritchard et al.
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A Danish study from the population-based database of the Danish Breast Cancer Cooperative Group evaluated postmenopausal patients with ER-positive high-risk breast cancer and also concluded that only one quarter of postmenopausal patients are free of excess mortality when omitting adjuvant CHT Ejlertsen et al. The reasons for these therapy effects in different age groups are probably multifactorial. A possible explanation might be a bias of selected therapies. It can be presumed that only patients without comorbidities, which are found more often in premenopausal patients, get an additional CHT.
This observation has already been made in a previous study of our group Inwald et al.
Another explanation might be incompliant long-term use of ET especially in postmenopausal patients Demissie et al. A study from an online breast cancer research registry showed that nonadherence among users was significantly associated with a lower financial status, a poorer relationship with the oncologist, and a prior switch in endocrine therapies Stanton et al.
However, low adherence to adjuvant ET increases the risk of death Makubate et al. Nevertheless, there are some limitations of this population-based study: These data primarily cover subnational or regional districts and might not reflect the entire population.
Translation of «Hormonpflaster» into 25 languages
The regional data might not be representative of international data due to regional variances, e. However, the strength of the data is that it reflects routine healthcare provisions. Consequently, these data can be used to analyze the structures of patient-centered care. We conclude that analysis of HR in patients with early breast cancer achieved very high quality in recent years due to implementation of guidelines and control mechanisms.
In line with current guidelines, the vast majority of HR-positive patients mostly received ET and this resulted in improved OS. Furthermore, our study showed differential effects of CHT and ET combination in premenopausal versus postmenopausal patients not previously described in a population-based cohort. In light of this positive finding, it is of major importance to track the minority of patients who did not receive appropriate therapy and to identify the reasons for this fatal deviation from current guidelines. No special or additional funding was obtained for the present project.
We thank Jennifer Dozier Ritter for language editing of the manuscript. This article does not contain any studies with human participants or animals performed of any of the authors.
National Center for Biotechnology Information , U. Journal of Cancer Research and Clinical Oncology. J Cancer Res Clin Oncol. Published online Aug 8. Treeck , and O. Klinkhammer-Schalke Tumor Center Regensburg e. Lindberg Tumor Center Regensburg e. Gerstenhauer Tumor Center Regensburg e.
Author information Article notes Copyright and License information Disclaimer. Received Jun 14; Accepted Jul This article has been cited by other articles in PMC. Abstract Purpose Adjuvant endocrine therapy ET is indicated in patients with steroid hormone receptor HR -positive breast cancer. Results Since , almost a complete rate of Conclusions Analysis of HR in patients with early breast cancer achieved a very high quality in recent years. Endocrine therapy, Steroid hormone receptor, Breast cancer, Overall survival, Cancer registry.
Introduction In addition to surgery and irradiation as local therapies, almost all patients with early breast cancer receive adjuvant systemic medical treatments. Open in a separate window. Analysis of HR Immunohistochemical determination of ER and PR was performed and quantified as the percentage of positivity of malignant cells and average intensity of coloration consistent with defined standards Prechtel and Prechtel Quality assurance methods Overall, six institutes of pathology were involved in these analyses.
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Distribution of HR-status across different pathologies To evaluate the inter-laboratory consistency, we investigated the distribution of patients in different institutes of pathology as well as the distribution of HR-status. Systemic therapies in HR-positive patients Overall, Survival effects as a function of menopausal state Application of CHT prior to ET led to different survival effects in both age groups Figs.
Discussion National and international guidelines strongly recommend the determination of HR-status in all patients with invasive breast cancer Kreienberg et al. Conclusions We conclude that analysis of HR in patients with early breast cancer achieved very high quality in recent years due to implementation of guidelines and control mechanisms.
Compliance with ethical standards Conflict of interest The authors declare that they have no conflict of interest. Human and animal rights statement This article does not contain any studies with human participants or animals performed of any of the authors. Anastrozole alone or in combination with tamoxifen versus tamoxifen alone for adjuvant treatment of postmenopausal women with early breast cancer: Adjuvant goserelin in pre-menopausal patients with early breast cancer: A holistic natural medicine treatment offers alternatives to conventional medicine.
It focuses on dysfunctional organ and hormone regulations and highlights the causes and interconnections. Here, the focused and cautious use of nature-identical hormones is a key to improving the condition. When you mention hormone therapy hormone treatment , most people think of synthetic hormones. This is not what we are talking about! In the case of sexual and stress hormones, we only use nature-identical hormones extracted from yam roots.
The healing of multiple hormone deficiencies is only possible, if all missing hormones are replaced in their appropriate quantity and at the same time. Hormones are team players! This requires the relevant diagnosis which provides a hormone overview, including their availability in the body at the start of the treatment: As long as Dinah is able to come to Europe personally, we can use her as our source. Please send as your application together with evidence that you are a yoga instructor and if possible your certificate of participation for the courses hormone yoga for menopause level I or level II.
All seminar prices include an extensive script in German or English ask for other languages , a certificate of participation and after a successful participation another certificate from Dinah Rodrigues that allows you to teach the learned exercises. Hormone Yoga is a combination of: Hatha Yoga, Kundalini Yoga and Tibetan energy techniques. The Hormone Yoga programme consists of body postures Asanas , specific breathing techiques and exercises for energy control. Since this is a holistic system, it not only stimulates the endocrine glands, but encourages the metabolism, activates the circulatory system and strengthens the immune system, too.
In combination with the right mindset and a healthy lifestyle, daily Hormone Yoga exercises can affect the endocrine glands in a positive way. For more information on Hormone Yoga see this book written by Dina Rodrigues in german language: This book should not be used to teach oneself following the explanations and pictures of the yoga exercises.
This version of the book does not include the latest adjustments that Dinah did to the exercises.
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Therefore, we recommend learn the Hormone Yoga exercices from a authorised Hormone Yoga teacher. Dinah Rodrigues herself is responsible for the authorisations and constantly works on her exercises.
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Video interview with Dinah Rodrigues german. Hormon Yoga wurde von Dinah Rodrigues, eine brasilianische Psychologin, Philosophin und erfahrene Yogalehrerin, entwickelt.